Early-onset breast cancer in Black women links most often to BRCA1 and BRCA2 variants

Black women experience disproportionately elevated risks of developing and dying from early-onset breast cancer. New research ...
ucdavis.edu

Understanding Why BRCA2 Is Linked to Cancer Risk

Ribbon structure of the BRCA2 protein. Mutations in the BRCA2 gene are linked to increased risk of breast cancer. New work from UC Davis shows how individual BRCA2 proteins work to repair damaged DNA, ...
Medical Xpress

BRCA2 research reveals a novel mechanism behind chemoresistance

One of the biggest challenges in cancer treatment is chemoresistance: Tumors that initially respond well to chemotherapy become resistant over time. When that happens, treatment options are often ...
Nature

BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping

Germline mutations in one allele of BRCA2 are associated with a high susceptibility to breast and ovarian cancers. Female carriers of one mutant BRCA2 allele have a cumulative probability throughout ...
Science Daily

First pictures of BRCA2 protein show how it works to repair DNA

Scientists have taken pictures of the BRCA2 protein for the first time, showing how it works to repair damaged DNA. The findings showed that each pair of BRCA2 proteins binds two sets of RAD51 that ...
ascopubs.org

Detecting BRCA2 Protein Truncation in Tissue Biopsies to Identify Breast Cancers That Arise in BRCA2 Gene Mutation Carriers

Lung Dose-Volume Parameters and the Risk of Pneumonitis for Patients Treated With Accelerated Partial-Breast Irradiation Using Three-Dimensional Conformal Radiotherapy We have developed an ...
News Medical

BRCA2 Gene Interactions

The BRCA1 and BRCA2 genes code for important tumor suppressor proteins. Also known of as the breast cancer type 2 susceptibility protein, BRCA2 is directly involved in the repair of damaged DNA.
technologynetworks

BRCA2 Requires a Specific Enzyme To Repair DNA Damage

Several years ago, it was discovered that a group of women with hereditary breast and ovarian cancer also have mutations in one of two genes, namely BRCA1 and BRCA2. Ever since, the genes and the ...
ascopubs.org

Sequence analysis of BRCA1 and BRCA2: correlation of mutations with family history and ovarian cancer risk.

Modeling the cost-effectiveness of granulocyte colony-stimulating factor use in early-stage breast cancer. A total of 238 women with breast cancer before age 50 or ovarian cancer at any age and at ...
News Medical

Structure of BRCA2 protein complex critical for DNA repair solved

The initials BRCA2 may be best known for a gene associated with many cases of breast cancer, and the protein encoded by the BRCA2 gene is critical to repairing breaks in DNA. The breakdown of this ...
EurekAlert!

Breakthrough in BRCA2 research: a novel mechanism behind chemoresistance discovered

Researchers found that losing a second protein, FIGNL1, allows cancer cells missing BRCA2 to restore DNA repair by reloading RAD51 onto broken DNA strands. Normally, BRCA2 helps place RAD51 at DNA ...