A cancer drug target already being investigated in clinical trials turns out to be doing something even more consequential ...

Discovery reshapes understanding of how tumor cells repair broken DNA, pointing toward more precise cancer therapies.

DPY30 was identified as a promoter of cancer cell proliferation and tumor survival. Targeting this protein may enhance the ...

Researchers at The University of Texas MD Anderson Cancer Center have identified an epigenetic target for replication stress, ...

New research reveals that triggering a cell’s DNA damage response could be a promising avenue for developing novel treatments against several rare but devastating viruses for which no antiviral ...

Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...

Oestrogen-induced DNA damage drives genomic instability in BRCA1 mutation cells, with dietary compounds showing protective potential.

Illustration of fork-MMEJ and BIR pathways in repairing single-ended DNA double-stranded breaks at broken replication forks, highlighting ATR-mediated regulation of the transition between these two ...